Experts from the Glycol Ethers group contributed to several publications over the last weeks both being published in “Regulatory Toxicology and Pharmacology.”

Propylene Oxide Derived Glycol Ethers: A Review of the Potential of Alkyl Glycol Ethers to Cause Endocrine Disruption

The extensive analysis of available literature and data concerning the endocrine-disrupting properties of P-series glycol ethers (PGE) revealed no significant evidence to support other published claims that PGE target endocrine organs or perturb endocrine pathways.

The main isomers in commercial propylene oxide derived (P series) glycol ethers are secondary alcohols that cannot oxidise to reproductive metabolites.

The acute vapour inhalation toxicity of 2-butoxyethanol. Points considered when designing and conducting a study in Guinea pigs and evaluating existing inhalation toxicity data on low volatility solvents

This article discusses results obtained from an acute inhalation toxicity study with guinea pigs by nose-only exposure to the substance 2-butoxyethanol at exposures close to the maximum attainable saturation vapour concentration.

The guinea pigs showed no adverse effects when exposed by inhalation to the saturated vapour of 2-butoxyethanol at 3 mg/L for 4 h. The authors note that the saturated vapour concentrations which were calculated according to thermodynamic laws cannot be reached in real testing setups. The overall conclusion can only be that 2-butoxyethanol vapour is expected to have a low acute inhalation toxicity to humans.